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Novel alkoxybenzamide inhibitors of poly(ADP-ribose) polymeraseMENEAR, Keith A; ADCOCK, Claire; FENANDEZ LENCE, Carlos et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 14, pp 3942-3945, issn 0960-894X, 4 p.Article

Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approachHARDCASTLE, Ian R; COCKCROFT, Xiaoling; GRIFFIN, Roger J et al.Journal of medicinal chemistry (Print). 2005, Vol 48, Num 24, pp 7829-7846, issn 0022-2623, 18 p.Article

Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinaseHOLLICK, Jonathan J; RIGOREAU, Laurent J. M; HUMMERSONE, Marc G et al.Journal of medicinal chemistry (Print). 2007, Vol 50, Num 8, pp 1958-1972, issn 0022-2623, 15 p.Article

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Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repairVEUGER, Stephany J; CURTIN, Nicola J; SMITH, Graeme C. M et al.Oncogene (Basingstoke). 2004, Vol 23, Num 44, pp 7322-7329, issn 0950-9232, 8 p.Article

Identification and optimisation of novel and selective small molecular weight kinase inhibitors of mTORMENEAR, Keith A; GOMEZ, Sylvie; SEBASTIAN, Luisa et al.Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 20, pp 5898-5901, issn 0960-894X, 4 p.Article

Poly(ADP-Ribose) Polymerase-1 Inhibitor Treatment Regresses Autochthonous Brca2/p53-Mutant Mammary Tumors In vivo and Delays Tumor Relapse in Combination with CarboplatinHAY, Trevor; MATTHEW, James R; CLARKE, Alan R et al.Cancer research (Chicago, Ill.). 2009, Vol 69, Num 9, pp 3850-3855, issn 0008-5472, 6 p.Article

Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibitionMCCABE, Nuala; TURNER, Nicholas C; SMITH, Graeme C. M et al.Cancer research (Baltimore). 2006, Vol 66, Num 16, pp 8109-8115, issn 0008-5472, 7 p.Article

Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1VEUGER, Stephany J; CURTIN, Nicola J; RICHARDSON, Caroline J et al.Cancer research (Baltimore). 2003, Vol 63, Num 18, pp 6008-6015, issn 0008-5472, 8 p.Article

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategyFARMER, Hannah; MCCABE, Nuala; MARTIN, Niail M. B et al.Nature (London). 2005, Vol 434, Num 7035, pp 917-921, issn 0028-0836, 5 p.Article

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Synthesis, crystal structure determination, and biological properties of the DNA-dependent protein kinase (DNA-PK) inhibitor 3-cyano-6-hydrazonomethyl-5-(4-pyridyl)pyrid-[1H]-2-one (OK-1035)STOCKLEY, Martin; CLEGG, William; FONTANA, Gabriele et al.Bioorganic & medicinal chemistry letters (Print). 2001, Vol 11, Num 21, pp 2837-2841, issn 0960-894XArticle